SPB may refer to:

Look up SPB in Wiktionary, the free dictionary.

• Saint Petersburg, Russia
• Saint Paul's Bay, Malta

• Shortest Path Bridging in the IEEE 802.1aq standard
• Slowly pulsating B star, a type of variable star
• Spindle pole body, the functional equivalent of the mammalian centriole in yeast
• Superpressure balloon

• Scappoose Industrial Airpark, Oregon, USA, FAA LID
• Schynige Platte Bahn, a mountain railway in Switzerland
• Charlotte Amalie Harbor Seaplane Base, U.S. Virgin Islands, IATA airport code SPB
• Shepherd's Bush railway station, London, National Rail station code SPB

• Society of the Precious Blood, Anglican religious order
• Socialist Party of Bangladesh, Political party in Bangladesh
• S. P. Balasubrahmanyam (1946–2020), Indian playback singer, actor, music director, voice actor and film producer
• SPB Software, mobile software developer
• Belarus Free Trade Union, a trade union in Belarus
• State Procurement Board in South Australia
• Sparisjóðabanki, also known as SPB hf., a defunct bank in Iceland
• SPB TV, a company

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