Berthoud is closest to the Northern Colorado Regional Airport (FNL ^IATA), which is north of the city, between Loveland and Fort Collins. United Airlines offers a "wingless flight" (AKA a bus) from here to DEN up to eleven times per day. Otherwise the airport is used by private charter flights. Getting from the airport to Berthoud generally requires a vehicle as taxis are uncommon in this part of Colorado.

Further away, but offering a wider range of national and international flights is Denver International Airport (DEN ^IATA). From Denver, the drive takes about an hour north on I-25. Groome Transport offers rides to Loveland for $32 per adult ($10 per child). However, the traveler is responsible for the trip from Loveland to Berthoud.

Berthoud is located north of Denver on I-25 between Loveland (North of Berthoud) and Longmont to the south.